Table 3 Brain regions showing a significant correlations between rWMD and scores on the UCLA Loneliness Scale, EQ and GSES scores.

From: White matter structures associated with loneliness in young adults

        

Using a mask related to EQ

Using a mask related to GSES

Brain region

R/L

x

y

z

t score

Corrected P (FDR)

Cluster size (kE)

t score

Corrected P (FDR)

Clustersize(kE)

β

t score

Corrected P(FDR)

Cluster size (kE)

β

IPL

R

41

−72

18

4.51

0.011*

238

4.51

0.001**

467

0.077

4.51

0.001**

660

0.122

 

R

62

-42

37

3.73

0.046*

3

3.73

0.005**

109

0.108

3.74

0.003**

68

0.075

 

L

−41

−46

36

5.33

0.004**

860

5.33

<0.001***

849

0.096

5.34

<0.001***

1534

0.145

pSTS

L

−62

−52

9

3.99

0.031*

15

3.91

0.004**

182

0.082

4.00

0.002**

52

0.044

AI

R

45

8

9

3.79

0.042*

2

3.79

0.005**

396

0.094

3.79

0.003**

398

0.123

pTPJ

L

−30

−79

40

3.81

0.041*

11

3.81

0.005**

253

0.098

3.81

0.003**

293

0.1

dmPFC

L

−17

60

10

4.02

0.029*

35

4.03

0.003**

89

0.061

4.03

0.002**

545

0.097

RLPFC

L

−29

41

9

3.77

0.043*

5

3.77

0.005**

247

0.073

3.75

0.003**

49

0.048

  1. *P  < 0.05, **P < 0.01, ***P < 0.001 Abbreviations: AI, anterior insula; dmPFC, dorsomedial prefrontal cortex; EQ, empathy quotient; GSES, generalized self-efficacy scale; FDR, false discovery rate; IPL, inferior parietal lobule; L, left; pSTS, post superior temporal sulcus; pTPJ, posterior tempo-parietal junction; R, right; ROIs, regions of interest; rWMD, regional white-matter density; RLPFC, rostro lateral prefrontal cortex.