Figure 4 | Scientific Reports

Figure 4

From: Identification of novel, therapy-responsive protein biomarkers in a mouse model of Duchenne muscular dystrophy by aptamer-based serum proteomics

Figure 4

ADAMTS5 is elevated in DMD, BMD and FSHD patient serum.

(a) ADAMTS5 abundance was measured by ELISA in serum samples from healthy control individuals (n = 18), DMD patients (n = 30), BMD patients (n = 30) and FSHD patients (n = 14). Data are shown as scatter plots showing individual replicates and box plots side-by-side. Error bars indicate mean +/− SEM. Box plots show median and interquartile range, whiskers represent the 10 to 90% range. Differences between groups were significant (P = 0.0023) as determined by one-way ANOVA. Bonferroni post hoc test significance values are indicated as **P < 0.01, *P < 0.05. (b) ROC curves for DMD, BMD and FSHD patients. AUC, Area Under the Curve.

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