Table 1 Top candidate serum protein biomarkers for DMD identified by SOMAscan.
Entrez ID Name | UniProt ID | Fold Change (mdx vs C57) | Dilution (%) | Restoration by PPMO | Reference |
|---|---|---|---|---|---|
PGAM1 Phosphoglycerate mutase 1 | P18669 | 136 | 5 | ++ | |
TNNI3 Troponin I, cardiac muscle | P19429 | 53 | 5 | +++ | |
MB Myoglobin | P02144 | 15 | 2 | ++ | |
TNNI2 Troponin I, fast skeletal muscle | P48788 | 14 | 5 | + | |
LDHB L-lactate dehydrogenase B chain | P07195 | 8.4 | 0.5 | ++ | |
FABP3 Fatty acid-binding protein, heart | P05413 | 7.8 | 5 | ++ | |
TPI1 Triosephosphate isomerase | P60174 | 5.7 | 2 | - | |
CAMK2B Calcium/calmodulin-dependent protein kinase type II subunit beta | Q13554 | 5.3 | 5 | ++ | |
CAMK2A Calcium/calmodulin-dependent protein kinase type II subunit alpha | Q9UQM7 | 4.1 | 5 | ++ | |
ANP32B Acidic leucine-rich nuclear phosphoprotein 32 family member B | Q92688 | 3.7 | 2 | ++ | |
CYCS Cytochrome c | P99999 | 3.6 | 2 | +++ | |
CAMK2D Calcium/calmodulin-dependent protein kinase type II subunit delta | Q13557 | 3.6 | 5 | ++ | |
PCNA Proliferating cell nuclear antigen | P12004 | 3.3 | 5 | ++ | |
HTRA2 Serine protease HTRA2, mitochondrial | O43464 | 3.1 | 5 | +++ | |
ADAMTS5 A disintegrin and metalloproteinase with thrombospondin motifs 5 | Q9UNA0 | 2.8 | 5 | +++ | |
PTPN11 Tyrosine-protein phosphatase non-receptor type 11 | Q06124 | 2.8 | 5 | ++ | |
LYN Tyrosine-protein kinase Lyn | P07948 | 2.7 | 5 | ++ | |
DUSP3 Dual specificity protein phosphatase 3 | P51452 | 2.5 | 5 | — | |
CAPN1 Calpain I | P07384 P04632 | 2.4 | 2 | +++ | |
THBS4 Thrombospondin-4 | P35443 | 2.2 | 2 | ++ | |
EDA2R Tumor necrosis factor receptor superfamily member 27 | P35443 | 2.1 | 5 | ++ | |
TYMS Thymidylate synthase | P04818 | −2.7 | 5 | ++ | |
SFN 14-3-3 protein sigma | P31947 | −3.2 | 2 | ++ |
