Figure 1
From: Folding of newly translated membrane protein CCR5 is assisted by the chaperonin GroEL-GroES
Structures of the GroEL-GroES chaperonin complex and CCR5-rubredoxin.
(a) GroEL consists of fourteen identical subunits arranged in a pair of seven-membered rings that are stacked back-to-back to form a double doughnut-like cylindrical structure and GroES consists of seven identical subunits arranged to form a domed disk (PDB 1SVT)25. The two rings of GroEL are shown in green and yellow and GroES is shown in orange. (b) The CCR5 chemokine receptor consists of seven hydrophobic transmembrane helices separated by alternating intracellular and extracellular loop regions (PDB 4MBS)36. The diagrams of GroEL-GroES and CCR5-rubredoxin are rendered at different scales.
