Figure 7
The characteristic free energy landscape is more rugged for the CENP-A nucleosome than for the H3 nucleosome.
(A) Free energy projection of the H3 nucleosome onto its first two principal components reveals two distinct conformational basins. (B) Free energy projection of the CENP-A nucleosome reveals four distinct conformational basins. White boxes highlight distinct free energy basins. Insets highlight key differences between representative structures for the numbered basins, consistent with the rest of our analysis. Structure figures rendered in VMD.
