Figure 3

The PS1^∆exon8 mutation transgene does not exacerbate the motor impairments exhibited by FAD Dutch APP.

(A) In the rotarod test, there was a significant decrease in average latency to fall in 6 month-old FAD Dutch APP and FAD Dutch APP/PS1^∆exon8 mice compared to Ntg and PS1^∆exon8-only mice. (B) There was also a significant decrease in average latency to fall in 18 month-old FAD Dutch APP and FAD Dutch APP/PS1^∆exon8 mice compared to Ntg and PS1^∆exon8-only mice. (C) In the pole test, there was a significant difference between FAD Dutch APP and Ntg in Tturn with FAD Dutch APP mice taking a significantly longer time to turn. (D) There was also a significant difference between FAD Dutch APP and FAD Dutch APP/PS1^∆exon8 in time compared to Ntg and PS1^∆exon8-only. In none of the behavioral assays utilized did the PS1^∆exon8 mutation exacerbate behavioral impairments relative to Dutch APP only. Black = Ntg, Red = PS1^∆exon8, Green = FAD Dutch APP, Blue = FAD Dutch APP/PS1^∆exon8. N = 29 Ntg, 30 PS1^∆exon8, 17 FAD Dutch APP and 12 FAD Dutch APP/PS1^∆exon8 (6 months) and 23 Ntg, 19 PS1^∆exon8, 9 FAD Dutch APP and 7 FAD Dutch APP/PS1^∆exon8 (18 months). N = 19 Ntg, 16 PS1^∆exon8, 11 FAD Dutch APP and 10 FAD Dutch APP/PS1^∆exon8 (pole test). Values represent means ± SEM, *p < 0.05, **p < 0.01, ***p < 0.001.