Table 1 Demographic and Disease Characteristics by age group.

From: Circulating HIV DNA Correlates With Neurocognitive Impairment in Older HIV-infected Adults on Suppressive ART

Parameters n = 44

Younger group (N = 18)

Older group (N = 26)

p

Age (years), median [IQR] a

32 [28.5, 34.8]

57 [53, 62.5]

—

Education (years), median [IQR] a

13 [12, 13]

13.5 [12, 16]

0.12

Male, n [%]

13 [72.2]

20 [76.9]

1

Caucasian, n [%]

8 [44.4]

20 [76.9]

0.05

Global Deficit Score a

0.2 [0.1, 0.7]

0.4 [0.2, 0.8]

0.24

Psychiatric Diagnoses

 Any Affective Disorder, n [%]

13 [72.2]

17 [65.4]

0.74

 Generalized Anxiety, n [%]

5 [27.8]

10 [38.5]

0.53

 Current MDD, n [%]

4 [22.2]

2 [7.7]

0.20

 Lifetime MDD, n [%]

13 [72.2]

16 [61.5]

0.53

 LT Alcohol Dependence, n [%]

6 [33.3]

8 [30.8]

0.52

 LT Alcohol Abuse, n [%]

3 [16.7]

6 [26.1]

0.71

 LT Other Substance Abuse, n [%]

5 [27.8]

11 [47.9]

1

 LT Other Substance Dependence, n [%]

8 [44.4]

13 [50]

0.77

 EDI (years)a

8.4 [2.6, 12.6]

17.4 [15.2, 21]

<0.0001

 Current CD4a

606 [494, 685]

722 [463.3, 901.3]

0.48

 Nadir CD4a

216.5 [121.8, 321.8]

231 [92, 317.3]

0.73

 Exposure ARVTs (years)a

3.9 [0.6, 8.8]

9.1 [6.0, 12.1]

0.009

 CPEa

7 [7, 7.8]

7 [6, 8]

0.5

  1. MDD = major depressive disorder; LT = lifetime; EDI = estimated duration of infection; CPE = CNS penetration effectiveness.
  2. aData shown as median [interquartile range].
  3. Significant differences between younger and older p are determined by Mann-Whitney or Fisher test, as appropriate. Significant p values in bold.
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