Figure 6 | Scientific Reports

Figure 6

From: Structures of the CDK12/CycK complex with AMP-PNP reveal a flexible C-terminal kinase extension important for ATP binding

Figure 6

CDK12 truncations show diminished activity against the RNA Pol II CTD.

Comparison of in vitro kinase activity against a GST-CTD substrate by various CDK12 complexes and CDK9/Cyclin T1 (FL denotes full length proteins). A representative autoradiograph detecting 32P-GST-CTD product is shown together with a graphic representation of 3 biological replicates of each phosphorylation reaction.

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