Figure 2

Representative raw ERG traces recorded from wild-type and MPS IIIB mice at the 28th and the 46th week showing the definitions for a- and b-waves.
(a) Isolated rod ERG measured with a stimulus below the operative range of cones. Amplitudes of the a-waves of wild-type and MPSIII animals are designated as AWT and AMPS, respectively. (b) Isolated cone ERG measured using a paired flash protocol in which rods were saturated by the conditioning flash. Amplitudes of the b-waves of wild-type and MPSIII animals are designated as BWT and BMPS, respectively.