Figure 6 | Scientific Reports

Figure 6

From: Electrophysiological and Histological Characterization of Rod-Cone Retinal Degeneration and Microglia Activation in a Mouse Model of Mucopolysaccharidosis Type IIIB

Figure 6

Bar charts comparing 46-week-old WT and MPS IIIB mice in terms of their retinal outer nuclear layer (ONL) thickness, number of cone soma, inner nuclear layer (INL) thickness and number of rod bipolar cells.

Data points and errors bars represent group means and standard errors, respectively. Statistics performed was 2-tailed unpaired t-test, with Welch correction where appropriate. Asterisk: p < 0.05; double asterisks: p < 0.001. (a,b) The MPS IIIB mice showed a highly significant thinning of the ONL, due to a significant loss of photoreceptor somas. Changes in the central and peripheral regions appeared to be concomitant. (c) There was only a minor reduction in the number of cone somas in the peripheral retina of MPS IIIB mice. Together the data suggested that there was a major loss in the rod population in the MPS IIIB mice. (d–e) There was also a significant general reduction in thickness of the inner nuclear layer in the MPS IIIB mice which may be partially caused by a loss in the rod bipolar cells population.

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