Table 2 Ratios of b-wave/a-wave. Values for rod-driven ERG were calculated from scotopic ERG data measured using stimulus strength of 112.2 isomerizations/rod, which was below the threshold for cones.

From: Electrophysiological and Histological Characterization of Rod-Cone Retinal Degeneration and Microglia Activation in a Mouse Model of Mucopolysaccharidosis Type IIIB

Rod/cone Origin

Group

b/a(28th week)

b/a (%) w.r.t. WT

b/a (46th week)

b/a (%) w.r.t. WT

Rod

WT

4.94

100

4.41

100

 

MPS IIIB

7.22

146.2

7.65

173.5

Cone

WT

6.75

100

6.42

100

 

MPS IIIB

7.83

116.1

7.96

123.8

  1. Values for cone-driven ERG were calculated from paired-flash data, in which rod activity was effectively suppressed.
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