Figure 7
aBocs and proton signaling are required for shaping the DAMP locomotion dynamics.
(a) Rates of decay of backward motion during the DAMP and outside of the DAMP for wild-type animals and aBoc deficient mutants. Inset: the temporal dynamics of pBoc aligned backward motion. (b) The slopes obtained from fitting a piecewise linear function to the scaled cumulative propensities of backward motion of pBoc deficient mutants. For each strain, the left and right bars correspond to the slope at t = −15..−5 sec and t = −5..0 sec prior to the aBoc, respectively (see also Fig. S7). The numbers of animals in each dataset are denoted in parentheses. Inset: the scaled cumulative propensities of backward motion are shown for the purpose of demonstration. Double asterisks in panels (a, b) denote a significant difference (p < 0.01). (c) A graphical representation of a model. The first detectable modulation of locomotion and the basal elevation in the propensity of backward motion are denoted by red circles and shaded areas, respectively. The intestinal calcium wave originates at the posterior just prior to the pBoc (vertical dotted line) and terminates at the anterior just prior to the aBoc. This period is denoted by the horizontal bracket. The observed dynamics of backward motion (orange curve) are shaped by additional signals, including proton signaling driven by the calcium wave between the Bocs. Inset: The mean wild-type dynamics of locomotion and body curvature overlaid on a single detailed timeline.
