Figure 1 | Scientific Reports

Figure 1

From: Towards An Advanced Graphene-Based Magnetic Resonance Imaging Contrast Agent: Sub-acute Toxicity and Efficacy Studies in Small Animals

Figure 1

Representative high (400X) magnification photomicrographs illustrating pulmonary and hepatic histology from chronic study animals at 1 mg/kg, 50 mg/kg, 100 mg/kg Mangradex and sham.

Lung (A) at 1 mg/kg, (B) at 50 mg/kg and (C) at 100 mg/kg- with pigment (arrows) within alveolar macrophages suggestive of the presence of graphene nanoparticles, (D) sham - without diagnostic abnormality. Liver – (E) at 1 mg/kg - showing minimal steatosis, but without diagnostic abnormality, (F) at 50 mg/kg- showing pigmented macrophage in Kupffer cells suggestive of graphene particles. No sign of inflammation, (G) at 100 mg/kg - more pigmented than at lower dose, (H) sham - without diagnostic abnormality.

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