Figure 4
From: Matrix metalloproteinase-12 is an essential mediator of acute and chronic arterial stiffening
MMP12 expression predicts SMC stiffness.
(A,B) Cross sections of uninjured and injured femoral arteries of male wild-type [uninjured (n = 8) and injured (n = 10)] and MMP12-null [uninjured (n = 8) and injured (n = 8)] mice were immunostained for FAKpY397 and p130CaspY410. Dashed lines show the internal and external elastic laminae as determined by autofluorescence. M; media. NI; neointima. Scale bar = 50 μm. (C,D) Quantification of results from panels (A,B). The bar graph shows mean + SE. (E) Single cross sections of human ascending aortas (n = 12) immunostained for MMP12, FAKpY397, or p130CaspY410. Results from three different patients with low (L), medium (M) and high (H) MMP12 staining are shown. (F,G) Linear regression analysis of all patients (n = 12) after immunostaining for MMP12 and either FAKpY397 or p130CaspY410.
