Figure 9
From: The role, mechanism and potentially novel biomarker of microRNA-17-92 cluster in macrosomia
A model was presented for miR-17-92 cluster mediated macrosomia.
The miR-17-92 cluster encodes for six distinct miRNAs. Drosha executes the initial step of miRNA processing in the nucleus and the resultant pre-miRNAs are exported to the cytoplasm where they are cleaved by Dicer to generate the final mature miRNAs. Up-regulation of Drosha and Dicer causes miR-17-92 overexpression, which drives macrosomia by inhibiting multiple negative regulators of cell cycle pathway that mediated the pathology of macromosia.
