Figure 6
Functional connectivity and damage.
(A) Functional networks for control and M-Aβ experiments. Gray links show all functional connections and color links correspond to the top functional connections (z - score > 1.95, 500 surrogates). The thickness of a link is proportional to its weight. The direction of the links is not shown for clarity. The control network reflects the stability of the network in two consecutive measurements. The M-Aβ network exhibits strong connectivity changes and reorganization of the network moduli, which are color coded according to the hierarchical tree information of Fig. 5. Grey clusters with a square in their center are those that fired independently or that participated equally in different communities. (B) Matrices of weight differences wd of the functional links. The clusters’ index order is the same as in Fig. 5 and corresponds to the unperturbed condition. The square boxes outline the moduli before perturbation. (C) Corresponding distributions of weight differences for the control and M-Aβ experiments. γ indicates the skewness of the distributions. The red vertical line is a guide to the eye to show the symmetry of the distribution in the control case. (D) Comparison of the distributions including all 15 experimental realizations. The M-Aβ distribution is broader and contains both strongly weakened and strongly strengthened functional links.
