Figure 8
Homogeneous cultures.
(A) Raster plots of spontaneous activity before (left) and after (right) application of M-Aβ complex. Spontaneous activity fell by 65% on average. (B) Ratio of the normalized firing rate for homogeneous (averaged over 5 experiments with the respective standard error of the mean) and clustered cultures (15 experiments) and comparing the behavior of the two kind of cultures for the M, Aβ and M-Aβ perturbations. Both culture types behaved similarly except for the M-Aβ condition, where the homogeneous cultures exhibited a significantly higher decay in activity. (*p < 0.05, Kolmogorov-Smirnov test.)
