Table 1 Genetic and phenotypic characterization of Guizhou/China type 1 cVDPVs.

From: An Insight into Recombination with Enterovirus Species C and Nucleotide G-480 Reversion from the Viewpoint of Neurovirulence of Vaccine-Derived Polioviruses

Virus

Nucleotide and amino acid of neurovirulence determinants

Recombination with EV-C

Neurovirulence (Log PD50)

5′-UTR

5′-UTR

5′-UTR

VP4

VP3

VP1

3D

3′-UTR

nt476

nt480

nt525

nt935

aa65

nt2438

aa225

nt2795

aa106a

nt6203

aa73

>nt7441

P1/Sabin

U

G

U

U

Ser

A

Met

A

Thr

C

His

G

—

>7.8

CHN8184

A

G

U

U

Ser

U

Leu

G

Ala

U

Tyr

A

No

2.7

CHN8229-1

A

G

U

G

Ala

U

Leu

G

Ala

U

Tyr

A

No

2.8

CHN8229-2

A

G

U

G

Ala

U

Leu

G

Ala

U

Tyr

A

No

3

CHN8229-3

A

G

U

G

Ala

U

Leu

G

Ala

U

Tyr

A

No

4

CHN8225c

A

G

U

U

Ser

U

Leu

G

Ala

U

Tyr

A

No

4.2

P1/Mahoney

U

A

U

G

Ala

U

Leu

G

Ala

U

Tyr

A

—

<2.0

HAI00-003b

U

A

U

G

Ala

A

Met

G

Ala

U

Tyr

A

Yes

2.8

Mindanao01-1b

U

A

U

G

Ala

A

Met

G

Ala

U

Tyr

A

Yes

2.4

  1. The nucleotides and amino acids that shared identity with those of the Sabin 1 strain are indicated by shaded boxes.
  2. asurface residues forming a part of NAg1.
  3. bRepresentative type 1 cVDPV strains from Hispaniola and The Philippines. The PD50 value is cited from the previous reports 8,9.
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