Figure 6
From: Alzheimer therapy with an antibody against N-terminal Abeta 4-X and pyroglutamate Abeta 3-X
NT4X mitigates neuron loss in Tg4-42hom mice.
Quantification of neurons in the CA1 of 6-months-old Tg4-42hom using unbiased stereology. Tg4-42hom mice that received weekly injections with the NT4X antibody or its respective Fab fragment, both an IgG control and a PBS control group for a period of 12 weeks as well as a group of non-treated mice were analyzed at 6 months of age. Tg4-42hom mice immunized with NT4X full length or Fab fragment both displayed significantly more neurons than same-aged untreated, IgG and PBS injected mice. In contrast, the number of neurons did not differ significantly between untreated, IgG and PBS injected Tg4-42hom mice. One-way analysis of variance (ANOVA) followed by Bonferroni multiple comparisons; n = 9–15 (Tg4-42hom NT: n = 9, Tg4-42hom NT4X: n = 15, Tg4-42hom IgG: n = 9, Tg4-42hom PBS n = 15). *p < 0.05; **p < 0.01; ***p < 0.001; data presented as mean ± S.E.M; NT = non-treated.
