Figure 6
From: Modeling the Transitions between Collective and Solitary Migration Phenotypes in Cancer Metastasis
The circuit response to Grb1 and Grb2 at different levels of the μ signal.
For both panels (a,b), the μ level for each phase diagram decreases from left to right. (a) For the thresholds of both the Gab1 and Grb2 signals to activate RhoA and Rac1 were set to be 500,000 molecules. At high levels of the microRNAs the 1st panel in Fig. 6a, only two phases are observed – {LL} and {LH}. As the level of μ decreases, the phases with solitary cell migration phenotypes become more common and many multistable phases appear. (b) The thresholds of both Gab1 and Grb2 to activate RhoA and Rac1 were set to be 250,000 molecules. All other parameters and the μ levels for each case are same as that in Fig. 6a. The color scheme for different phases is shown at the bottom.
