Figure 5
From: RBFOX3/NeuN is Required for Hippocampal Circuit Balance and Function
Granule cells of adult Rbfox3−/− mice exhibit increased frequency but normal amplitude of excitatory and inhibitory neurotransmission.
Schematics of patch clamp recording of granule cells in hippocampal slices for mEPSC (a) and mIPSC (e). Representative traces from recordings of mEPSC (b) and mIPSC (f). Frequency and cumulative probability are shown for mEPSC (c) and mIPSC (g). Amplitude and cumulative probability are shown for mEPSC (d) and mIPSC (h). (mEPSC: WT, n = 19 cells, 4 mice; KO, n = 21 cells, 4 mice; mIPSC: WT, n = 15 cells, 4 mice; KO, n = 15 cells, 4 mice). Student’s t-test, two tailed, ***P < 0.001. All data are presented as mean ± s.e.m. Scale bars represent 10 pA and 10 sec.
