Figure 3
From: Distinct predictive performance of Rac1 and Cdc42 in cell migration
Cross-cellular analysis of response functions.
(a) Schematic of the similarity analysis of the response functions of Rac1 (middle panel) and Cdc42 (right panel) between different cells. Both the ordinate and abscissa indicate indices of cells so that each matrix element represents the cosine similarity in the response functions between the pair of cells specified by the element’s indices. (b) Predictability of response functions of Rac1 (middle panel) and Cdc42 (right panel) between different cells. Each matrix element represents the correlation between the observed edge displacement in a specific cell (‘target cell’) and the predicted edge displacement in the target cell decoded based on the response function of another cell (‘reference cell’). The ordinate and abscissa denote the indices of the target cell and the reference cell, respectively. (c) Relationship between the mode of the cell migration and the contributions of Rac1 (middle panel) and Cdc42 (right panel) to the morphological change. The contributions of Rac1 and Cdc42 were evaluated via predictability, which corresponds to the diagonal elements in (b). Each dot represents a single cell, where cell numbers with blue and red dots correspond to those in (b), respectively. The migration mode was evaluated via the lateral propagation speed of the edge displacement, which was quantified based on the speed of the wave propagation, which is indicated with a red dashed line in the spatiotemporal auto-correlation function (left insets).
