Table 2 Endogenous metabolites of the serum from CP-induced rats and their identification results (mean ± SD, n = 6).

From: Ginseng alleviates cyclophosphamide-induced hepatotoxicity via reversing disordered homeostasis of glutathione and bile acid

No.

T R (min)

Molecular ion

Measured mass (Da)

VIP

Formula

Metabolites

Relative Intensity

HMDB

KEGG

BK

CP

CP+G

M1

9.25

[M+H]+

524.3712

26.43

C26H54NO7P

LysoPC (18:0)

98.53 ± 6.81

145.51 ± 8.73**

107.49 ± 5.78#

10384

C04230

M2

7.50

[M+H]+

274.2743

7.39

C11H23N5O3

Valylarginine

18.47 ± 4.89

24.67 ± 5.79*

20.49 ± 4.31

29121

–

M3

7.59

[M+H]+

544.3393

10.49

C28H50NO7P

LysoPC (20:4)

247.83 ± 10.44

337.47 ± 14.73**

269.84 ± 12.83##

10395

C04230

M4

9.25

[M+H]+

546.3525

12.46

C28H52NO7P

LysoPC (20:3)

231.74 ± 9.83

296.58 ± 12.81*

287.37 ± 10.99

10394

C04230

M5

4.67

[M+H]+

400.3403

2.16

C23H45NO4

L-Palmitoylcarnitine

49.39 ± 4.28

87.33 ± 8.83**

52.17 ± 6.68#

00222

C02990

M6

5.11

[M+H]+

347.2217

3.22

C21H30O4

Cortexolone

24.36 ± 5.47

46.32 ± 8.99**

41.36 ± 6.84

00015

C05488

M7

5.64

[M+H]+

372.3108

4.17

C21H41NO4

Myristoylcarnitine

10.35 ± 3.28

17.93 ± 4.12*

15.49 ± 4.08

05066

–

M8

6.39

[M+H]+

426.3578

3.98

C25H47NO4

Oleoylcarnitine

37.72 ± 7.76

55.74 ± 8.58*

35.37 ± 5.76##

05065

–

M9

6.80

[M+H]+

468.3088

5.65

C22H46NO7P

Lyso PC (14:0)

184.38 ± 13.36

222.73 ± 17.41*

204.28 ± 12.84

10379

C04230

M10

7.75

[M+H]+

262.1160

4.59

C11H19NO6

Succinylcarnitine

9.76 ± 1.35

17.82 ± 2.32*

10.73 ± 2.21#

61717

–

M11

6.25

[M+H]+

318.3035

3.57

C18H39NO3

Phytosphingosine

14.86 ± 2.35

29.65 ± 3.44**

19.76 ± 3.32#

04610

C12144

M12

7.39

[M+H]+

520.3399

20.34

C26H50NO7P

LysoPC (18:2)

204.93 ± 18.48

154.32 ± 9.38**

229.39 ± 14.57##

10386

C04230

M13

7.82

[M+H]+

496.3398

9.465

C24H50NO7P

LysoPC (16:0)

358.39 ± 15.18

312.43 ± 12.19*

316.48 ± 14.74

10382

C00157

M14

9.74

[M+H]+

550.3869

14.58

C28H56NO7P

LysoPC (20:1)

198.42 ± 9.87

147.35 ± 8.47*

154.91 ± 9.15

10391

C04230

M15

8.42

[M+H]+

522.3553

11.49

C26H52NO7P

LysoPC (18:1(11Z))

152.88 ± 8.76

113.36 ± 7.90*

142.37 ± 10.27#

10385

C04230

M16

1.98

[M+H]+

249.0615

4.78

C9H15N2O6

γ-glutamylthreonine

34.43 ± 4.62

26.67 ± 5.32*

45.32 ± 5.44##

00713

–

M17

2.15

[M+H]+

251.0696

4.39

C8H14N2O5S

γ-glutamylcysteine

21.43 ± 3.25

15.38 ± 2.36*

19.48 ± 2.41#

01049

C00669

M18

4.20

[M-H]−

391.2847

8.94

C24H40O4

Chenodesoxycholic acid

4.78 ± 0.43

10.98 ± 1.03**

4.69 ± 0.76#

00951

C05465

M19

3.82

[M-H]−

391.2841

4.32

C24H40O4

Deoxycholic acid

18.47 ± 6.87

31.75 ± 7.86**

20.86 ± 8.86#

11637

C05122

M20

3.75

[M-H]−

514.2834

17.70

C26H45NO7S

Tauroursocholic acid

21.37 ± 4.90

12.47 ± 4.01**

19.35 ± 5.78#

00889

–

M21

1.90

[M-H]−

212.0029

12.67

C8H7NO4S

Indoxyl sulfate

13.25 ± 3.25

27.33 ± 5.24**

17.79 ± 4.38#

03309

–

M22

8.33

[M-H]−

283.2646

4.41

C18H36O2

Stearic acid

89.24 ± 6.96

149.75 ± 14.38**

107.84 ± 12.47#

00827

C01530

M23

3.12

[M-H]−

445.1892

6.33

C24H30O8

Estrone 3-glucuronide

14.23 ± 4.39

23.46 ± 5.49**

17.85 ± 5.77#

04483

C11133

M24

4.92

[M-H]−

329.2330

3.47

C22H34O2

Docosapentaenoic acid

12.93 ± 3.31

27.37 ± 3.38**

28.84 ± 6.49

06528

C16513

M25

3.88

[M-H]−

512.2680

10.25

C26H43NO7S

Glycolithocholate sulfate

9.73 ± 3.18

28.64 ± 6.42**

22.87 ± 6.43

02639

C11301

M26

6.07

[M-H]−

389.2687

4.68

C24H38O4

7a-Hydroxy-3-oxo-5β- cholanoic acid

3.58 ± 0.67

5.48 ± 0.89*

4.46 ± 0.87

00503

C00281

M27

5.39

[M-H]−

407.2797

4.60

C24H40O5

Cholic acid

5.63 ±1.01

8.64 ± 0.82*

7.52 ± 1.56

02639

C11301

M28

6.71

[M-H]−

429.3010

3.52

C27H42O4

7a-Hydroxy-3-oxo-4- cholestenoate

6.87 ± 0.95

9.32 ± 0.99*

7.10 ± 1.02#

12458

C00157

M29

3.88

[M-H]−

512.2676

5.42

C26H43NO7S

Sulfolithocholylglycine

46.25 ± 6.42

24.17 ± 4.32**

32.29 ± 4.48#

00619

C00695

M30

2.02

[M-H]−

203.0836

2.98

C11H12N2O2

Tryptophan

16.48 ± 3.11

9.78 ± 1.07*

10.74 ± 1.21#

00929

C00525

M31

4.82

[M-H]−

464.3012

23.83

C26H43NO6

Glycocholic acid

31.03 ± 5.11

24.56 ± 6.47*

29.47 ± 8.79

00138

C01921

M32

8.62

[M-H]−

566.3456

23.93

C30H50NO7P

LysoPC (22:6)

197.33 ± 12.54

135.83 ± 11.25*

147.78 ± 10.83

10404

C04230

M33

4.43

[M-H]−

188.0724

4.44

C11H11NO2

3-Indolepropionic acid

12.44 ± 1.24

8.49 ± 0.87*

10.82 ± 0.90#

02302

–

  1. BK for blank group, CP for CP treated group and CP+G for CP and ginseng co-treated group. Compared with BK, *p < 0.05 and **p < 0.01; Compared with CP, #p < 0.05 and ##p < 0.01.
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