Figure 3
From: Targeted exosome-mediated delivery of opioid receptor Mu siRNA for the treatment of morphine relapse
siRNA-RVG exosomes reduced MOR levels in mice.
(A) qRT-PCR analysis of MOR siRNA levels in the brains of mice following injection with various quantities of exosome. (B) qRT-PCR analysis of MOR siRNA concentration in the plasma of mice untreated or treated with empty exosomes, siRNAs in normal exosome, scramble RNAs in RVG exosome or siRNAs in RVG exosome. (C) qRT-PCR analysis of MOR siRNA concentration in the brains of mice following intravenous injection as described in (B). (D) qRT-PCR analysis of MOR mRNA levels in the brains of mice treatment as described in (B). (E) Western blot analysis of MOR protein levels in the brains of mice treated as described in (B). (F) Quantification of the MOR protein levels in (B). n = 7, *P < 0.05; **P < 0.01.
