Figure 6
Interactions of positively selected genes and differentially expressed genes involved in the adaptation of F. cancrivora to high salinity.
Red italics denote candidate positively selected genes, blue italics indicate significantly up-regulated genes and green italics genes experiencing positive selection and increased expression. (1) AVPR2, expressed mainly in kidney tubules, primarily serves to respond to the pituitary hormone arginine vasopressin (AVP) to maintain water homeostasis; production of ALB can facilitate blood plasma volume expansion, which serves to regulate blood pressure. (2) AGT, PREP, ANPEP and CTSA play roles in the renin-angiotenin system pathway; NR3C2, PIK3CG, PDPK1 and SCNN1G associate with aldosterone-regulated sodium reabsorption pathway. (3) EHHADH provides energy for tubule reabsorption through the oxidation of fatty acids in the proximal tubule; ATP6V1G3 and ATP6V1F are v-type-H+ ATPases and they participate in Na+ uptake as energizers.
