Figure 4 | Scientific Reports

Figure 4

From: M1 and M3 muscarinic receptors may play a role in the neurotoxicity of anhydroecgonine methyl ester, a cocaine pyrolysis product

Figure 4

AEME concentration-response curve normalized to the maximum acetylcholine response. CHO cells expressing rat M1, rat M3 and rat M5 were studied (data represent the mean of three independent experiments, each one performed in triplicate).

The AEME concentration effect was greater than 100 μM for both rat M1 and rat M3. The averages of absolute values of control are: 21950 ± 133, 23107 ± 77 and 20117 ± 1323 arbitrary units/4 × 104 cells for rat M1, rat M3 and rat M5, respectively. Data presented as mean ± SEM.

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