Figure 3
Distribution of the allelic fraction.
(a) The allelic fraction of all identified somatic mutations (all sites) and non-silent sites identified by WES. The distribution of allelic fraction between all sites and non-synonymous sites differed significantly (Kolmogorov-Smirnov test, P < 2.2 × 10−16). For the transcribed tumor-mutated alleles, the distribution of the allelic fractions (b) and correlation (c) between mRNA and genome are shown (n = 2061). For translated tumor-mutated alleles, the distribution of the allelic fractions at the protein levels and the corresponding genome and transcriptome (n = 174) (d) and the correlation in any two of pairwise comparisons (e–g). The y-axis in a, b and d is the probability density of allelic fraction.
