Figure 3
The solid black line in each panel shows an FTIRM spectrum (amide I region) obtained from (A) fibrils of α-syn expressed in E. coli, (B) normal brain tissue from the patient with AD, (C) the core of an SP, (D) normal brain tissue from the brain of the patient with PD, (E) the core of an LB and (F) the halo of an LB.
Blue and red lines represent contributions of β-sheet structures and non-β-sheet structures (random coils, α-helices and others), respectively. The dotted line represents the fitted curve. Data were fitted using a Gaussian species model centred at 1628, 1680 (β-sheets, blue line), 1648 and 1661 (random coils, α-helices and others, red line) cm−1 12,30,31.
