Table 1 FTIR deconvolution.

From: Synchrotron FTIR micro-spectroscopy for structural analysis of Lewy bodies in the brain of Parkinson’s disease patients

Wavelength (cm−1)

1628

1648

1661

1680

β-sheet

A: the fibrils of recombinant α-syn (Area %)

40.9

14.4

29.2

15.5

56.4

B: Normal brain tissue of AD (Area %)

8.4

46.0

20.3

25.3

33.7

C: the core of SP (Area %)

22.1

34.5

21.8

21.6

43.7

D: Normal brain tissue of PD (Area %)

16.1

34.5

29.4

20.0

36.1

E: the core of LB (Area %)

19.2

40.4

11.2

29.2

48.4

F: the halo of LB (Area %)

44.9

11.7

24.5

18.9

63.8

  1. A–F correspond to the panels in Fig. 3. The deconvolution indicates that the β-sheet content of the halo of an LB (63.8%) is higher than that of the core of an LB (48.4%) and SP (43.7%). In particular, the proportion of the area under the peak at 1628 cm−1, which represents the amount of β-sheet structures, in the halo is as high as that in the fibrils of recombinant α-syn.
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