Figure 3 | Scientific Reports

Figure 3

From: Human embryonic stem cell-derived mesenchymal cells preserve kidney function and extend lifespan in NZB/W F1 mouse model of lupus nephritis

Figure 3

hESC-MSCs reduce proteinuria and kidney damage scores in BWF1 mice.

(A) Analysis of average proteinuria score for weeks 33–35 in an age-matched subset of BWF1 lupus prone mice, treated with a low dose of hESC-MSCs (50k cells, n = 10, gray columns) or high dose (500k, n = 10, white), compared to controls (n = 9, black) (*p < 0.05, Mann-Whitney). (B–D) Average renal histopathology scores for glomeruli (B), protein cast formation (C) and interstitial inflammation (D). n = 9 control and n = 9 hESC-MSC (500k) (p < 0.05, Mann-Whitney).

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