Figure 6 | Scientific Reports

Figure 6

From: Human embryonic stem cell-derived mesenchymal cells preserve kidney function and extend lifespan in NZB/W F1 mouse model of lupus nephritis

Figure 6

hESC-MSC treated animals display reduced serum cytokines and metabolites.

(A) BUN levels in pre-disease (15 weeks of age, n = 5) (gray column), week 35 control (n = 9, black) and 500k hESC-MSC-treated (n = 9, white) BWF1 mice. (B) Serum creatinine levels in pre-disease (15 weeks of age, n = 5) (gray column), week 35 control (n = 9, black) and 500 k hESC-MSC-treated (n = 9, white) BWF1 mice. (*p < 0.05, ctrl vs. hESC-MSC, Mann-Whitney). (C,D) Cytokine levels of TNFα (C) and IL-6 (D) in pre-disease (15 weeks of age, n = 8), control (n = 12) and hESC-MSC-treated (n = 10) BWF1 mice (**p < 0.0005 for pre-disease vs ctrl; *p < 0.05 for ctrl vs. hESC-MSC, Mann-Whitney).

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