Figure 2
From: Epigenomic Reprogramming of Adult Cardiomyocyte-Derived Cardiac Progenitor Cells
Single-cell transcriptomic differences between parental cardiomyocytes (Ctl) and their derived cardiac progenitor cells (mCPC).
(a) Principle Component Analysis (PCA) plot of single-cell whole transcriptome profiled by Affymetrix GeneChip microarray. Each blue or red dot represents a single cardiomyocyte (Ctl) or mCPC, respectively. (b) Hierarchical clustering of differentially expressed genes with |fold-change| ≥ 1.5 plus P = 0.05; (FDR-adjusted p ≤ 0.05). (c) Gene ontology enrichment analysis (GOEA): Percent down- or up-regulated genes passed FDR-adjusted p ≤ 0.05 in the groups of different gene ontology categories, including myofilaments and cellular structure, ion channels and cell cycle and proliferation were plotted, with Enrichment Scores shown on the right. Ctl: mature cardiomyocytes; mCPC: Mouse cardiomyocyte-derived cardiac progenitor cells.
