Figure 6
From: Epigenomic Reprogramming of Adult Cardiomyocyte-Derived Cardiac Progenitor Cells
Integrated pathway enrichment analysis based on differentially expressed genes (DEGs) and differentially methylated genes (DMGs).
The “cardiac muscle contraction pathway” is enriched by both DEGs and DMGs based on KEGG knowledge database using the DEGs detected by Affymetrix GeneChIP and the DMGs detected by CHARM 2.1M arrays (p ≤ 0.05). The down-regulation of most genes in this pathway (left, green color shaded genes) in mCPCs vs. adult cardiomyocytes is well orchestrated with their DNA hypermethylation (right, genes annotated with non-black colors have relative methylation level ≥25% in mCPCs vs control cardiomyocytes). The enrichment p value for Cardiac Muscle Contraction pathway is 5.452 × 10−9 for gene expression and 0.000249 for DNA methylation.
