Figure 4
From: An outbreak caused by GII.17 norovirus with a wide spectrum of HBGA-associated susceptibility
Comparison of P domain amino acid of the GII.17 outbreak virus (DG42) with other GII.17 strains.
GII.17 strains were composed of those active in neighboring regions and countries during 2014-15 NoV epidemic season (Genbank accession number: BAR42289, AKB94545 and BAP33934) and strains circulating in the past decades (Genbank accession number: ACT%20368315, ABD95934, AII73747, AAS86786 and AFN06732). The three conserved HBGA-binding interfaces are indicated by red empty rectangles (dashed lines), the surrounding amino acids of HBGA binding site are marked by blue shadow. Residues in the binding site and surrounding regions were highly conserved during 1978–2008. Two mutations in the conventional GII HBGA binding sites and four residues in the surrounding regions next to the binding site were also different for the newly emerged variant of 2014-15 NoV epidemic seasons.
