Figure 3
Bivalent, active and repressive domains are cell type-specific during somatic cell reprogramming.
(A) The number of active, repressive and bivalent domains in MEFs, pre-iPSCs and iPSCs. (B) Venn diagram shows the overlap of bivalent domains in the three cell stages. Less than 10% of the bivalent domains are common among MEFs, pre-iPSCs and iPSCs. Most bivalent domains are formed during reprogramming. (C) Domains in MEFs (indicated at bottom) are changed to other states during reprogramming. The detailed proportion for each category is labelled. The same transitions from MEFs to pre-iPSCs and to iPSCs are shaded. (D) Mesodermal marker gene Col1a1 located within an active domain in MEFs, is silenced by a bivalent domain in iPSCs (left). Pluripotent marker gene Tcfcp2l1 located within a repressive domain in MEFs is activated by an active domain in iPSCs (right).
