Table 2 Metabolic signature of BU in human patients.
From: Metabolomic profiles delineate mycolactone signature in Buruli ulcer disease
Metabolism | Biochemical Pathway | Metabolite | Fold change (Patient vs Ctrl) | p-value | q-value |
|---|---|---|---|---|---|
Amino acid | Histidine | histidine | 0,85 | 0,002 | 0,090 |
Lysine | N6-acetyllysine | 0,80 | 0,010 | 0,172 | |
Phenylalanine and Tyrosine | p-cresol sulfate | 0,64 | 0,006 | 0,146 | |
Cysteine and Methionine | S-methylcysteine | 0,67 | 0,049 | 0,388 | |
Glutathione | 5-oxoproline | 0,84 | 0,002 | 0,090 | |
Peptide | Dipeptide | glycylvaline | 2,03 | 0,000 | 0,023 |
isoleucylglycine | 1,21 | 0,038 | 0,334 | ||
phenylalanylleucine | 1,60 | 0,008 | 0,169 | ||
Gamma-glutamyl amino acid | gamma-glutamylisoleucine | 0,77 | 0,046 | 0,386 | |
gamma-glutamylmethionine | 0,81 | 0,025 | 0,295 | ||
Fibrinogen cleavage peptide | ADSGEGDFXAEGGGVR | 1,47 | 0,029 | 0,316 | |
DSGEGDFXAEGGGVR | 1,63 | 0,002 | 0,090 | ||
Carbohydrate | Hexose | fructose | 1,50 | 0,031 | 0,316 |
mannose | 1,51 | 0,000 | 0,023 | ||
Glycolysis and Gluconeogenesis | glucose | 1,15 | 0,001 | 0,090 | |
Nucleotide Sugar and Pentose | xylulose | 1,40 | 0,003 | 0,119 | |
Energy | TCA cycle | citrate | 0,84 | 0,012 | 0,184 |
malate | 0,67 | 0,001 | 0,090 | ||
Lipid | Monohydroxy fatty acid | 4-hydroxybutyrate (GHB) | 0,72 | 0,048 | 0,388 |
2-hydroxyoctanoate | 0,74 | 0,028 | 0,316 | ||
3-hydroxyoctanoate | 0,74 | 0,011 | 0,181 | ||
2-hydroxystearate | 1,18 | 0,011 | 0,181 | ||
2-hydroxypalmitate | 1,21 | 0,006 | 0,146 | ||
Beta-oxidation | palmitoylcarnitine | 0,66 | 0,012 | 0,181 | |
oleoylcarnitine | 0,63 | 0,008 | 0,169 | ||
Bile acid | glycodeoxycholate | 0,58 | 0,010 | 0,172 | |
glycolithocholate sulfate | 0,33 | 0,000 | 0,023 | ||
taurolithocholate 3-sulfate | 0,42 | 0,006 | 0,146 | ||
Glycerolipid | choline | 0,91 | 0,035 | 0,334 | |
Lysolipid | 1-oleoylglycerophosphoethanolamine | 0,71 | 0,009 | 0,169 | |
2-oleoylglycerophosphoethanolamine | 0,74 | 0,032 | 0,316 | ||
1-linoleoylglycerophosphoethanolamine | 0,73 | 0,028 | 0,316 | ||
1-palmitoylglycerophosphocholine | 0,88 | 0,042 | 0,367 | ||
2-palmitoylglycerophosphocholine | 0,73 | 0,024 | 0,284 | ||
1-oleoylglycerophosphocholine | 0,83 | 0,038 | 0,334 | ||
1-linoleoylglycerophosphocholine | 0,74 | 0,005 | 0,146 | ||
2-linoleoylglycerophosphocholine | 0,70 | 0,005 | 0,146 | ||
1-dihomo-linoleoylglycerophosphocholine | 0,73 | 0,009 | 0,169 | ||
Monoacylglycerol | 1-stearoylglycerol (1-monostearin) | 1,25 | 0,038 | 0,334 | |
Sphingolipid | sphinganine | 0,55 | 0,001 | 0,090 | |
Sterol/Steroid | cholesterol | 1,13 | 0,020 | 0,243 | |
cortisol | 1,42 | 0,018 | 0,237 | ||
cortisone | 1,26 | 0,007 | 0,157 | ||
Nucleotide | Purine | xanthine | 1,27 | 0,004 | 0,146 |
inosine | 2,01 | 0,004 | 0,146 | ||
Cofactor | Heme | bilirubin (Z,Z) | 0,44 | 0,037 | 0,334 |
bilirubin (E,E) | 0,28 | 0,014 | 0,204 | ||
biliverdin | 0,66 | 0,019 | 0,243 | ||
Vitamin | Riboflavin | riboflavin (Vitamin B2) | 1,82 | 0,048 | 0,388 |
Tocopherol | gamma-CEHC | 0,67 | 0,017 | 0,236 | |
Xenobiotic | Chemical | 4-methylcatechol sulfate | 0,74 | 0,016 | 0,221 |
hexaethylene glycol | 1,20 | 0,030 | 0,316 | ||
octaethylene glycol | 1,15 | 0,031 | 0,316 | ||
pentaethylene glycol | 1,13 | 0,049 | 0,388 |
