Figure 1
Both Exogenous and Endogenous BM-MSCs are Present In Fibrotic Mouse Liver.
Hepatic fibrosis was induced in WT-BALB/c mice by administration of CCl4 for 4 weeks. Control group received olive oil treatment. Then EGFP-positive MSCs were infused via tail vein injection. (A,B)The fluorescence microscope and flow cytometry were employed to detect EGFP-positive MSCs in livers of each groups. (C) Mice model schematic. WT-BALB/c mice were lethally irradiated and received BMT including EGFP-positive BMSCs and EGFP-negative whole BM cells. Then hepatic fibrosis was induced by administration of CCl4 for 4 weeks. (D) EGFP-positive MSCs appear in the stroma of fibrosis livers.(The mouse drawing in C was drawn by Xue Yang).
