Figure 5
Dynamic changes of SDF-1α with development of hepatic fibrosis.
(A) Real-time PCR was used to detect dynamic changes of SDF-1α in liver and bone marrow with development of hepatic fibrosis at the 0th, 2nd, 4th, 6th and 8th week after CCl4 administration. The mRNA expression was normalized against β-actin. (B) At different time points during CCl4-induced liver fibrosis in BMT mice, mice were sacrificed and frozen section of the liver tissue was made and then the homing of EGFP-MSCs were observed under fluorescence microscope. (C) At different time points in CCl4-induced liver fibrosis mice with EGFP-MSCs injected via tail vein, mice were sacrificed and frozen section of the liver tissue was made and then the homing of EGFP-MSCs were observed under fluorescence microscope (D).
