Table 2 Representative differentially expressed genes by LC28-0126 in healthy subjects.

From: Drug Signature-based Finding of Additional Clinical Use of LC28-0126 for Neutrophilic Bronchial Asthma

Gene symbol

Gene name

Protein function

CV1 at 0 hr

Signaling pathway

Fold change(6 hr/0 hr)

p value2

PLA2G4A

phospholipase A2, group IVA (cytosolic, calcium-dependent)

Generic phospholipase

0.241

Arachidonic acid metabolism

1.55

0.0365

ADRB1

adrenergic, beta-1-, receptor

Generic receptor

0.216

β-adrenergic regulation

1.96

0.0133

CD36

CD36 molecule (thrombospondin receptor)

Generic receptor

0.356

Oxidative stress

1.71

0.0844

PDK4

pyruvate dehydrogenase kinase, isozyme 4

Protein kinase

0.171

PDH-dependent glucose oxidation

−3.31

0.0002

  1. 1Coefficient of variation
  2. 2p value between 0 hr and 6 hr, two-sided t-test.
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