Table 3 Top ranked statistically significant connections of LC28-0126 with reference drug profiles.
ATC1 | ATC classification | CMAP instance | Concentration | Cell line | Set size | Query length | Score | P value | Standardized score |
|---|---|---|---|---|---|---|---|---|---|
R03DA01 | DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES | Dyphilline | 15.8 uM | MCF7 | 2 | 24 | 0.3728 | 0.00010 | 4.1185 |
N07CA01 | OTHER NERVOUS SYSTEM DRUGS | Betahistine | 17.2 uM | PC3 | 1 | 24 | 0.4484 | 0.00004 | 3.8125 |
G04AB03 | UROLOGICALS | Pipemidic Acid | 13.2 uM | MCF7 | 1 | 24 | 0.4005 | 0.00034 | 3.4050 |
N/A2 | 5186223 | 12 uM | MCF7 | 1 | 24 | 0.3914 | 0.00048 | 3.3274 | |
C01BC04 | CARDIAC THERAPY | Flecainide | 8.4 uM | PC3 | 2 | 24 | 0.1995 | 0.00100 | 3.2787 |
C05AA11 | VASOPROTECTIVES | Fluocinonide | 8 uM | MCF7 | 3 | 24 | −0.3693 | 0.00010 | −3.9616 |
R05DB21 | COUGH AND COLD PREPARATIONS | Cloperastine | 11 uM | MCF7 | 3 | 24 | −0.2523 | 0.00020 | −3.9635 |
N/A | Sirolimus | 0.1 uM | MCF7 | 2 | 24 | −0.4078 | 0.00010 | −4.0492 | |
C01BC03 | CARDIAC THERAPY | Propafenone | 10.6 uM | MCF7 | 2 | 24 | −0.3833 | 0.00010 | −4.0797 |
A07EA07 | ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS | Beclometasone | 7.6 uM | MCF7 | 1 | 24 | −0.4967 | 0.00001 | −4.2229 |
