Figure 4
Xanthurenic acid (XA) displays antipsychotic-like activity in mice challenged with MK-801.
(A) Locomotor activity in mice pre-treated with saline (vehicle) or two doses of XA (30 or 60 mg/kg, i.p.) for 60 min and then challenged with MK-801. Locomotor activity was expressed both as a function of time in 5 min beans (left) and as the sum of the total travelled distance in the habituation and hyperactivity phases (right). Values are means + S.D. of 6–8 determinations. p < 0.05 (One-way ANOVA + Fisher’s LSD) vs. values of the hyperactivity phase obtained in mice that did not receiveMK-801 (i.e., mice treated with veh + veh) (*), or vs. values obtained in mice treated with MK-801 without pre-treatment with XA (veh + MK-801); F(3,25) = 36.142. Veh = vehicle. (B) Same as in A) in mGlu2−/− mice. Here, only the dose of 60 mg/kg of XA was tested. Values are means + S.D. of 6–8 determnations. (C) Same as in A), but in normal mice treated i.p. with LY341495 (1 mg/kg) combined with either vehicle or XA (60 mg/kg) for 60 min and challenged with MK-801.
