Figure 3

Effects of TACE gene silencing on plaque components in three groups of rabbits.

(A–C) Representative RAM-11 immunostaining showing the macrophage content in the Control group (A), Mock group (B) and TACE shRNA group (C) at week 16; (D–F) Representative Oil red O staining showing the lipid content in the Control group (D), Mock group (E) and TACE shRNA group (F) at week 16; (G–I) Representative α-actin immunostaining showing the content of smooth muscle cells in the Control group (G), Mock group (H) and TACE shRNA group (I) at week 16; (J–L) Representative Sirius red staining showing the collagen content in the Control group (J), Mock group (K) and TACE shRNA group (L) at week 16; (M) Quantitative analysis of (A–C); (N) Quantitative analysis of (D–F); (O) Quantitative analysis of (G–I); (P) Quantitative analysis of (J–L). ⁺ P < 0.05 vs. Control group, ^{+ +} P < 0.01 vs. Control group, ^# P < 0.05 vs. Mock group, *P < 0.01 vs. Mock group. Bar = 250 μm.