Figure 1 | Scientific Reports

Figure 1

From: A novel, native-format bispecific antibody triggering T-cell killing of B-cells is robustly active in mouse tumor models and cynomolgus monkeys

Figure 1

Description of bispecific antibody format.

(a) Alignment of the sequences of the CH3 domain of human IgG1 and IgG3. (b) Localization of the Fc* substitution within the crystal structure of human IgG1. Residues that are conserved between IgG1 and IgG3 are shown in yellow; H435 and Y436 are shown in magenta; other non-conserved residues are shown in green. (c) Schematic diagram of bispecific antibody format. Heavy chain variable regions of different specificity are in red and cyan; common light chain variable regions are in orange.

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