Figure 4 | Scientific Reports

Figure 4

From: A novel, native-format bispecific antibody triggering T-cell killing of B-cells is robustly active in mouse tumor models and cynomolgus monkeys

Figure 4

Effects of REGN1979 on tumor growth in in vivo mouse tumor models.

(a) Raji tumor cells were co-implanted with human PBMCs subcutaneously into NSG mice and treated with the indicated amount of REGN1979 or a control antibody via intraperitoneal injection twice a week starting at day 0 for the length of the study. No tumor growth was observed at all dose levels of REGN1979 tested. (b) Raji tumor cells were co-implanted with hPBMCs and tumors were allowed to develop until they reached the indicated initial volume (either 200–400 mm3 or 500–900 mm3). Treatment was then initiated with REGN1979 or a control antibody. These were dosed twice weekly for the duration of the study. Animals dosed with REGN1979 showed complete tumor regression in both initial tumor sizes.

Back to article page