Figure 5 | Scientific Reports

Figure 5

From: A novel, native-format bispecific antibody triggering T-cell killing of B-cells is robustly active in mouse tumor models and cynomolgus monkeys

Figure 5

Effects of REGN1979 on circulating B cells and on cytokine levels in cynomolgus monkeys.

(a) Cynomolgus monkeys were injected with a single dose of REGN1979 (1 mg/kg) and levels of peripheral B and T cells were examined by flow cytometry. Treatment with REGN1979 resulted in complete depletion of measurable circulating B cells for at least 60 days post dose and a transient loss of circulating T cells. (b) Cytokine levels were measured at the indicated time post dose. Compared to pre-dose levels, treatment with REGN1979 resulted in transient increase in all measured cytokines, which returned to base line levels by T = 24 hours. (c) Levels of REGN1979 in circulation are shown for the three animals in the cohort (I06879, I06880, I06881). LLoQ represents the lower limit of quantification for the assay.

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