Figure 6 | Scientific Reports

Figure 6

From: A novel, native-format bispecific antibody triggering T-cell killing of B-cells is robustly active in mouse tumor models and cynomolgus monkeys

Figure 6

Depth of killing of B cells in peripheral lymphoid tissues of cynomolgus monkeys treated with REGN1979.

Cynomolgus monkeys were dosed with the indicated amounts of REGN1979 or rituximab and levels of circulating B and T cells were analyzed by FACS (a). Seven days post dose the animals were sacrificed and levels of B cells in the peripheral lymphoid tissues were examined by tissue FACS as described in Methods (b).

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