Figure 7 | Scientific Reports

Figure 7

From: A novel, native-format bispecific antibody triggering T-cell killing of B-cells is robustly active in mouse tumor models and cynomolgus monkeys

Figure 7

Depth of killing of B cells in peripheral lymphoid tissues of cynomolgus monkeys treated with REGN1979, immunohistochemical analysis.

Seven days post dose with the indicated amounts of REGN1979 or rituximab, the animals were sacrificed and the indicated peripheral lymphoid tissues were stained with anti-CD20 antibodies. Similar results were obtained with antibodies against the B cell markers, CD19 and CD79a (data not shown). Spl, spleen; MsLN, mesenteric lymph nodes; Thy, thymus.

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