Table 1 Newly identified loci associated with waist circumference (WC)/WHR variation in Asian-ancestry populations.

From: Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference

Nearby gene

Chr

SNP

Allelesa

EAFb

StageIP

Stage II P

Stage I & II

EV(%)e

Number

β (SE)c

P d

WCadjBMI

EFEMP1

2

rs3791679

A/G

0.21

1.43E-13

3.63E-02

64454

2.87(0.38)

4.86E-14

0.03%

ADAMTSL3

15

rs8030379

A/G

0.76

1.62E-09

NA

50668

2.46(0.41)f

1.62E-09

0.02%

CNPY2

12

rs3809128

C/T

0.80

3.74E-09

NA

30368

3.69(0.63)f

3.74E-09

0.04%

GNAS

20

rs2057291

G/A

0.73

4.02E-08

NA

38613

2.52(0.46)f

4.02E-08

0.02%

WHRadjBMI

NID2

14

rs1982963

A/G

0.81

1.41E-12

1.71E-03

56208

4.82(0.62)

1.07E-14

0.07%

HLA-DRB5

6

rs5020946

T/G

0.41

4.38E-09

1.13E-01

49519

3.15(0.52)

1.30E-09

0.05%

WCnoBMI

CEP120

5

rs10051787

T/C

0.40

1.07E-09

1.40E-03

60909

3.96(0.58)

7.23E-12

0.08%

TSC22D2

3

rs1868673

C/A

0.48

1.49E-08

NA

36247

4.36(0.77)f

1.49E-08

0.09%

SLC22A2

6

rs368123

G/A

0.39

1.00E-06

7.29E-03

62430

3.16(0.57)

2.64E-08

0.05%

  1. aShown as: effect allele/other allele.
  2. bEffect allele frequency in Asian-ancestry populations, estimated from stage I studies.
  3. cPer allele effect of SNPs in percentile of standard deviation, derived from meta-analysis.
  4. dDerived from meta-analysis. The P values for the combined data were adjusted for both study-specific inflation factors and the estimated inflation factor for the stage I meta-analysis statistic.
  5. eExplained variance, estimated from combined stage I and II data.
  6. fStage I results are shown.
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