Figure 6 | Scientific Reports

Figure 6

From: Antagonism of Nav channels and α1-adrenergic receptors contributes to vascular smooth muscle effects of ranolazine

Figure 6

Representation of the vascular effects of ranolazine involving Nav channel inhibition in vascular myocytes and in sympathetic nerve endings and α1-adrenergic receptor antagonization.

Nav: voltage-gated sodium channels; Cav: voltage-gated calcium channels, NCX: sodium-calcium exchanger; IP3R: IP3 receptor; SR: sarcoplasmic reticulum. The dotted arrow illustrates Cav channel antagonism as reported previously by Deng et al.24 and Malavaki et al.25

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