Figure 6 | Scientific Reports

Figure 6

From: Integrating longitudinal serum IL-17 and IL-23 follow-up, along with autoantibodies variation, contributes to predict bullous pemphigoid outcome

Figure 6

MMP-9 secretion is regulated by IL-17 and IL-23 and varied along the treatment.

Lymphocytes, monocytes and polymorphonuclear cells (PMN) were isolated from 5 healthy controls and stimulated with IL-17 (200 pg/ml), IL-23 (100 pg/ml) or both cytokines for 20 hours (mononuclear cells) or 1 hour (PMN). MMP-9 secretion was analysed by gel zymography. One representative zymogram was shown for each type of cells and quantification of zymogram was performed using ImageJ software (a). MMP-9 secretion was analysed by gel zymography in BP patients in remission or with relapse at diagnosis and at day 60 (b).

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